Much of what we believe about the biopsychology of drug addiction is based on the study of drug self-administration in laboratory animals,but there is a major cause for concern:

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The concern arises from the fact that much of the research on drug addiction has focused on stimulant self-administration (such as cocaine and amphetamines) and the conditions under which laboratory animals are kept and tested are often unnatural. These factors can influence the behavior of the animals and the outcomes of the studies, potentially limiting the applicability of the findings to understanding human drug addiction.

Much of What We Believe About the Biopsychology of Drug