During development,the keratinocytes of the various skin layers express different keratins and other intracellular proteins involved in the maturation of the skin.Transglutaminase 1 is one such protein.What is the human syndrome that can be caused by mutations in Transglutaminase 1?

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Mutations in Transglutaminase 1 can lead to the human syndrome called Lamellar ichthyosis. This is because this protein is important for the maturation of the outer layer of the skin, and its deficiency can lead to the characteristic dry, scaly skin seen in this disorder. Dowling-Meara EBS, Junctional epidermolysis bullosa, Bullous congenital ichthyosiform erythroderma, Incontinentia pigmenti, and Hypohidrotic ectodermal dysplasia are caused by mutations in other genes or proteins.

During Development,the Keratinocytes of the Various Skin Layers Express Different