In humans,there are a spectrum of syndromes,including spondylocostal dysostosis and Klippel-Feil anomaly,that are characterized by vertebral and rib abnormalities.Genetic mapping studies have identified mutations in several genes that affect one growth factor signaling pathway.Which is the pathway affected?

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The NOTCH signaling pathway is known to play a crucial role in the development of vertebrae and ribs, and mutations in genes affecting this pathway are associated with conditions like spondylocostal dysostosis and Klippel-Feil anomaly.

In Humans,there Are a Spectrum of Syndromes,including Spondylocostal Dysostosis and Klippel-Feil