Hypohidrotic ectodermal dysplasia can be life threatening due to a child's inability to thermoregulate,which can result in hyperpyrexia or hyperthermia.The gene mutations causing this syndrome have now been identified.Which signaling pathway is affected?

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Hypohidrotic ectodermal dysplasia is caused by mutations in the EDA/EDAR signaling pathway, which is part of the TNF family of signaling pathways. This affects the development of hair, teeth, and sweat glands, which can lead to thermoregulation issues and hyperpyrexia or hyperthermia. The other signaling pathways listed (WNT, SHH, FGF, BMP) do not play a role in this specific condition.

Hypohidrotic Ectodermal Dysplasia Can Be Life Threatening Due to a Child's