An ultrasound of a 7-month-pregnant woman reveals the presence of oligohydramnios.Closer examination suggests that the fetus has bilateral renal agenesis.What could have led to the development of this congenital anomaly?

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Bilateral renal agenesis suggests the absence of both kidneys, which likely resulted from a failure of the ureteric bud (derived from the mesonephric duct) to interact properly with the metanephric blastema (derived from the intermediate mesoderm). This failure of interaction can lead to a lack of kidney formation and subsequently to oligohydramnios. Both the dorsal aorta and WT1 and RET expression play roles in renal development, but they are not directly related to bilateral renal agenesis.

An Ultrasound of a 7-Month-Pregnant Woman Reveals the Presence of Oligohydramnios.Closer