Development of the sensory regions of the inner ear involves the formation of hair cells and supporting cells by the process of lateral inhibition controlled by Notch signaling.How would overexpression of the transcription factors Hes1 and 5,which are modulated by Notch signaling,be expected to affect the number of hair cells or supporting cells?

Question

Quizplus · Accepted Answer

Overexpression of Hes1 and 5, which are modulated by Notch signaling, would be expected to increase the overall number of supporting cells because Notch signaling is involved in lateral inhibition, which controls the formation of hair cells and supporting cells. Overexpression of Hes1 and 5 would disrupt this process, leading to an increase in the number of supporting cells.

Development of the Sensory Regions of the Inner Ear Involves