Biopsy of a lesion of the buccal mucosa shows epithelial cells with hyperchromatic and pleomorphic nuclei. Abnormal mitotic figures are found at all levels in the epithelium. The basement membrane is intact. This is consistent with:

Question

Quizplus · Accepted Answer

The description of epithelial cells with hyperchromatic and pleomorphic nuclei, abnormal mitotic figures at all levels in the epithelium, and an intact basement membrane is consistent with carcinoma in situ. This condition represents a severe dysplasia that has not yet invaded past the basement membrane, distinguishing it from invasive squamous cell carcinoma.

Biopsy of a Lesion of the Buccal Mucosa Shows Epithelial