What Physiological and Environmental Mechanisms Contribute to Nocturnal Asthma Symptoms

What physiological and environmental mechanisms Contribute to nocturnal asthma symptoms
I.Sleep state-induced parasympathetic tone
II.Increased lung volume and subsequent airway smooth muscle uploading
III.Circadian rhythms
IV.Reduced nocturnal body temperature
V.Gastroesophageal reflux
VI.Obstructed sleep apnea

A) I, II, III, and IV
B) II, III, IV, and V
C) I, II, III, V, and VI
D) I, III, IV, V, and VI