Statistics Clearly Demonstrate That There Are Significantly More Cases of a Disease

Statistics clearly demonstrate that there are significantly more cases of a disease in one particular neighborhood than in all the rest of the city. Assuming all else is the same, which of the following is the most likely explanation for a single neighborhood having such a different pattern of illness?

A) A cultural or ethnic concentration in the neighborhood
B) The geographical location of the neighborhood within the city
C) A statistical fluke without meaning
D) The time of year the different statistics were collected throughout the city