The signaling pathways triggered by Toll-like receptors typically result in activation of which of the following pairs of transcription factors?
A)NFAT and T-bet
B)AP-1 and GATA-3
C)Fos and STAT-6
D)NF$\kappa$B and AP-1
E)Lck and Jun

Question

Quizplus · Accepted Answer

The predominant signaling pathway used by Toll-like receptors (TLRs)results in the activation of the NF-F$\kappa$B transcription factor.Ligand binding to the TLR at the cell surface leads to recruitment of several cytoplasmic signaling molecules through specific domain-domain interactions,resulting in degradation of I$\kappa$B and subsequent activation of NF$\kappa$B.In some cell types,certain TLRs also engage other signaling pathways,such as the MAP kinase cascade,leading to activation of the AP-1 transcription factor.T-bet and GATA-3 are transcriptional regulators involved in helper T cell differentiation.Fos is a component of AP-1,and STAT-6 is a transcription factor activated by IL-4 binding to cells.Lck is not a transcription factor,but rather a tyrosine protein kinase involved in antigen-receptor signaling in T cells.

The Signaling Pathways Triggered by Toll-Like Receptors Typically Result in Activation