A 15-year-old girl develops malaise,headache,and low-grade fever,followed by pharyngitis and cervical lymph node enlargement as a result of infectious mononucleosis caused by Epstein-Barr virus (EBV).Her acute symptoms resolve within 2 weeks,and the fatigue improves within 3 months.Following the primary infection described in this patient,the patient's subsequent exposure to Epstein-Barr virus (EBV)will trigger clonal expansion of EBV-specific T cells expressing which one of the following surface molecules? A)CD62L^high B)CD44^low C)CD45RA^high D)CD45RO^high E)CD21^high

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After primary infection,subsequent exposure to Epstein-Barr virus (EBV)(i.e. ,secondary infection)will trigger clonal expansion of EBV-specific memory T cells.Memory T cells express CD45RO.CD45RA is expressed on naive human T cells.CD62L,or L-selectin,is a peripheral lymph node homing receptor that is expressed at high levels on naive T lymphocytes but not on activated or memory T lymphocytes.CD44 is an adhesion molecule that is expressed at low levels on naive T lymphocytes and at high levels on activated and memory T lymphocytes.CD21 is actually the EBV receptor,but it is expressed on B cells (and follicular dendritic cells).It normally functions as a coreceptor to deliver activating signals in B cells.

A 15-Year-Old Girl Develops Malaise,headache,and Low-Grade Fever,followed by Pharyngitis and Cervical