The initial cellular events that are induced by antigen-mediated cross-linking of the B cell receptor (BCR)complex include all of the following EXCEPT:

Question

Quizplus · Accepted Answer

In the initial events after antigen binding to the B cell receptor,B cells migrate out of,not into,the lymph node follicles and toward the T cell zones by increasing expression of CCR7,a chemokine receptor that responds to chemokines produced in the T cell zone.Helper T cells play an important role in the activation of B cells,inducing proliferation,isotype switching,and somatic mutation both by the release of cytokines as well as through direct interactions with the B cell via CD40L.T cell-mediated activation of B cells can only occur in the presence of protein antigens.Other early events that occur in B cell activation include increased proliferation and time spent in mitosis,increased expression of B7 to enhance the B cell's ability to activate T cells,increased expression of the anti-apoptotic protein bcl-2 to promote survival,and increased expression of cytokine receptors to enhance survival and proliferative signals coming from T cells.

The Initial Cellular Events That Are Induced by Antigen-Mediated Cross-Linking