Up to half of the IgG found in the serum of a normal individual is produced by which of the following cells?
A)Naive B cells in lymph nodes
B)Activated B cells in the spleen
C)B cells in germinal centers of lymph nodes
D)B lymphocytes in the gastrointestinal tract
E)Long-lived plasma cells in the bone marrow

Question

Quizplus · Accepted Answer

During a humoral immune response,naive B cells differentiate into antibody-producing cells,and some of these migrate to the bone marrow,where they can reside and produce antibodies for years.Many of these cells are called plasma cells,based on their histologic appearance.Naive B cells do not secrete antibodies.Although activated B cells in spleen or lymph node germinal centers produce large amounts of antibody during an active humoral immune response,they do not account for most of the serum IgG normally.Intestinal B cells secrete large amount of IgA,which is transported into the lumen.

Up to Half of the IgG Found in the Serum