Mrs.Johnson is a 37-year-old woman who has been taking medication for lower back pain for the last 18 months.She reports to her physician that although the medication initially rendered her pain-free,she now receives very little relief from her daily dose.This situation is described by which of the following terms used to refer to drug responsiveness (assuming that her condition has not actually worsened)?

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Hypersensitivity describes an allergic or immune-mediated response to a drug,which can be serious,requiring airway maintenance or ventilatory assistance.An idiosyncratic effect is one that is unusual,opposite to,or has no effect compared with the predicted usual effect in an individual.Tolerance describes a decreasing intensity of response to a drug over time.Tachyphylaxis describes a rapid decrease in response to a drug.

MrsJohnson Is a 37-Year-Old Woman Who Has Been Taking Medication