The greatest limitation to patient use of a dry powder inhaler (DPI)is

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Although patient preference may have a large effect on patient compliance,sufficient inspiratory flows are necessary to deliver aerosolized medication through a DPI.Because DPIs are breath-actuated devices,the need for patient coordination is reduced compared with delivery devices such as metered dose inhalers (MDIs).Flow rates of 30 to 90 L/min are necessary for effective delivery of medication from a DPI.Cost of DPI and MDI may be similar depending on medication availability.

The Greatest Limitation to Patient Use of a Dry Powder