A direct-acting cholinergic agent often used in bronchial challenge tests to assess the degree of airway activity is

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Edrophonium is used in the Tensilon test to determine whether muscle weakness is caused by overdosing with an indirect-acting cholinergic agent or undertreatment with insufficient drug.The methacholine challenge is a lung function test used to help diagnose reactive airways.Neostigmine is used to increase muscle strength in patients with myasthenia gravis.Phospholine is an organophosphate used in insecticides (a cholinesterase reactivator)that may have lethal effects via initial stimulation and then blockade of cholinergic receptors.

A Direct-Acting Cholinergic Agent Often Used in Bronchial Challenge Tests