The keyhole theory indicates that the larger the side-chain attachment to a catechol base,the

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Duration of action is not affected by the side-chain attachment.All catecholamines are rapidly inactivated by COMT.Duration of action of all catecholamines is readily limited by COMT.The theory that explains the shift from $\alpha$activity to $\beta$₂ specificity has been termed the keyhole theory of $\beta$sympathomimetic receptors: The larger the side-chain attachment to a catechol base,the greater the $\beta$₂ specificity.If the catecholamine structural pattern is seen as a keyhole shape,the larger the "key" (side chain),the more$\beta$₂ specific is the drug.

The Keyhole Theory Indicates That the Larger the Side-Chain Attachment β\betaβ

The Keyhole Theory Indicates That the Larger the Side-Chain Attachment $\beta$