Which of the Following Statements Regarding Ipratropium Bromide Are True $\beta$

Which of the following statements regarding ipratropium bromide are true?
1) It is a first-line choice of bronchodilator for chronic obstructive pulmonary disease (COPD) .
2) It can be combined with a $\beta$ agonist for maintenance bronchodilation in COPD.
3) It is added to a $\beta$ agonist in severe asthma episodes that do not respond to a $\beta$ agonist alone.
4) It is a leukotriene modifier used to treat step 3 asthma.

A) 1 and 4 only
B) 2 and 4 only
C) 1,2,and 4 only
D) 1,2,and 3 only