Disadvantages of theophylline therapy include which of the following?
1)Narrow therapeutic margin
2)Toxic effects
3)Unpredictable blood levels
4)Need for individual dosing
5)Numerous drug-drug and drug-condition interactions

Question

Quizplus · Accepted Answer

The narrow therapeutic margin of theophylline provides a small target level of proper dosing.Outside of its narrow therapeutic margin,theophylline may cause toxic side effects such as supraventricular tachycardia,convulsions,or hematemesis.The fact that individuals often metabolize theophylline at different rates makes it even more difficult to determine dosing that provides serum levels within the narrow therapeutic margin.Individual dosing creates the need for multiple serum level draws and often the constant titration of dosages.Theophylline interacts with many drugs that patients may require for treatment of myriad disease processes,such as F1F1F1S1F1F1F10 blockers,corticosteroids,F1F1F1S1F1F1F10 agonists,and the influenza vaccine.Even disease processes themselves may affect a patient's serum levels (e.g. ,pneumonia,congestive heart failure,and renal failure).

Disadvantages of Theophylline Therapy Include Which of the Following