General contraindications for mucoactive therapy include which of the following?
1) Forced expiratory volume in 1 second (FEV₁) greater than 25% of predicted
2) Gastroesophageal reflux
3) End-stage pulmonary disease
4) Acute exacerbation of chronic obstructive pulmonary disease (COPD)

Question

Quizplus · Accepted Answer

Generally,if FEV₁ is less than 25% of predicted,it becomes difficult to mobilize and expectorate secretions.With profound airflow compromise,secretion clearance theoretically could decline.Mucoactive therapy should be used with caution in patients with severely compromised vital capacity and expiratory flow,such as in the presence of end-stage pulmonary disease or neuromuscular disorders.Gastroesophageal reflux and inability of the patient to protect the airway are risk factors for postural drainage,if that is necessary with mucoactive therapy.Mucoactive agents should be discontinued if there is evidence of clinical deterioration.Patients with acute bronchitis or exacerbation of chronic disease (cystic fibrosis and COPD)may be less responsive to mucoactive therapy,possibly because of infection and muscular weakness,which can reduce airflow-dependent mechanisms further.

General Contraindications for Mucoactive Therapy Include Which of the Following