Precautionary measures that are suggested when administering pentamidine to reduce the risk of both drug exposure and tuberculosis (TB)infection include
1)use a nebulizer system with one-way valves and expiratory filter.
2)administer aerosol in a negative-pressure room.
3)do not expose pregnant women and nursing mothers to the drug.
4)use barrier protection.
5)stop nebulization if the patient takes the mouthpiece out of the mouth.

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The following precautionary measures are suggested when administering pentamidine to reduce the risk of both drug exposure and TB infection with aerosolized pentamidine:
The following precautionary measures are suggested when administering pentamidine to reduce the risk of both drug exposure and TB infection with aerosolized pentamidine:
1.Use a nebulizer system with one-way valves and expiratory filter.
2.Administer aerosol in a negative-pressure room,with six air changes per hour,or consider using an isolation booth/hood assembly with an exhaust fan and air directed through a high-efficiency filter.
3.Pregnant women and nursing mothers should avoid exposure to the drug,and all practitioners should limit exposure to the extent possible.
4.Use barrier protection (gloves,mask,and eyewear)for health care workers.
5.Stop nebulization if the patient takes the mouthpiece out of the mouth (a thumb control on the power gas tubing gives more control).
6.Use nebulizers producing a mass median diameter (MMD)of 1 to 2 µm to increase alveolar targeting and lessen large airway deposition and cough production.
7.Always use a suitable expiratory filter and one-way valves with the nebulizer.Instruct patients to turn off the nebulizer when talking or when taking it out of the mouth.
8.Screen patients for cough history and pretreat with a β agonist with sufficient lead time for effect in reducing bronchial reactivity.
9.Screen patients with human immunodeficiency virus (HIV)infection for TB,and treat where evidence of infection exists.
10.Do not allow treatment patients to mix with other patients until coughing subsides.
11.Health care workers should periodically screen themselves for TB.

Precautionary Measures That Are Suggested When Administering Pentamidine to Reduce