The major adverse reaction to antimycobacterial agents such as isoniazid and rifampin is

Question

Quizplus · Accepted Answer

An elevation in liver enzymes has been reported in patients receiving isoniazid and is reversible with discontinuation of the drug.Rare cases of serious hepatitis and death also have been reported.Hepatotoxicity usually occurs between the 4th and 8th weeks of treatment but may occur at any time.Tests used to measure hepatocellular injury should be performed and include monitoring liver transaminases such as alanine aminotransferase (ALT)and aspartate aminotransferase (AST).In addition,patients should be monitored for the development of symptoms of hepatitis such as nausea,loss of appetite,and abdominal pain.Hepatotoxicity is the major adverse reaction associated with rifamycins (of which rifampin is one).Elevations in liver transaminases are commonly reported and are usually reversible on discontinuation of the drug.Patients with preexisting liver damage are more prone to rifamycin-induced hepatotoxicity.

The Major Adverse Reaction to Antimycobacterial Agents Such as Isoniazid