Atracurium and cisatracurium are eliminated by

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Quizplus · Accepted Answer

Atracurium and cisatracurium differ from other neuromuscular blocking agents regarding route of elimination.These agents are partly inactivated by a spontaneous degradation mechanism that is dependent on the pH of blood and temperature of the body.This nonenzymatic breakdown is termed Hofmann degradation.In addition to Hofmann degradation,these agents are rapidly converted to less active metabolites by circulating plasma esterases that cause hydrolysis of the compounds.Because of the lack of liver and kidney elimination,atracurium and cisatracurium provide optimal choices for patients with hepatic or renal failure.

Atracurium and Cisatracurium Are Eliminated by