Thiazide diuretics work by

Question

Quizplus · Accepted Answer

Thiazide diuretics block NaCl reabsorption at the distal tubule.Loop diuretics are often called "high-ceiling" diuretics because they can cause 20% of the filtered load of NaCl and water to be excreted in the urine.They inhibit the reabsorption of NaCl at the thick ascending limb of the loop of Henle,where about 20% of filtered NaCl is usually reabsorbed.Carbonic anhydrase inhibitors (CAIs)prevent the normal breakdown of carbonic acid and decrease bicarbonate reabsorption.CAIs also inhibit NaCl reabsorption at the proximal tubule.The decreased osmotic gradient for water reabsorption results in increased delivery of NaHCO₃,NaCl,and water from the proximal tubule.Osmotic diuretics are freely filtered at the glomerulus but are not reabsorbed.These agents remain in the tubule lumen and impair the ability of the proximal tubule and thick ascending limb of the loop of Henle to reabsorb NaCl.The net result is that osmotic substances are potent diuretics that lead to increased excretion of water and NaCl.

Thiazide Diuretics Work by