Drugs that directly influence circadian mechanisms are often referred to as

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Drugs that directly influence circadian mechanisms are often referred to as chronobiotics.Chronobiology is concerned with the mechanisms of periodic biologic influences on health and disease.Chronopharmacology,or the study of time-dependent variations in pharmacology,was developed from the inclusion of chronobiologic principles in the study of pharmacology.Traditionally,drug delivery has assumed that a chemical is absorbed predictably from the site of administration.A second-generation drug delivery goal has been the achievement of a continuous constant rate (i.e. ,zero-order)delivery of drugs.However,living organisms are not "zero-order" in their response to drugs.They are predictable resonating dynamic systems governed by intrinsic oscillators,so they require different amounts of drug at different times within the circadian cycle to maximize the desired and undesired (i.e. ,chronotoxicity)effects of the drug.

Drugs That Directly Influence Circadian Mechanisms Are Often Referred to as