A computer program recognizes an ORF by looking for ribosomal binding sites,start codons,and stop codons with an appropriate number of nucleotides between each element.What is a drawback of this approach?
A) Too many ORFS are identified, most of which are stretches on non-coding junk DNA.
B) Codon bias causes incorrect annotations.
C) Unusual, but legitimate genes and non-coding RNA may be missed.
D) We lack the computing power to complete the analyses in a timely manner, thus many genomes are only partially annotated.

Question

Quizplus · Accepted Answer

This approach is limited to identifying ORFs that meet specific criteria for ribosomal binding sites, start codons, and stop codons. However, there may be genes and non-coding RNA that do not fit these criteria and would be missed by this method. This is a potential drawback of using this approach for genome annotation.

A Computer Program Recognizes an ORF by Looking for Ribosomal