TCRs associate with the adapter molecule

Question

Quizplus · Accepted Answer

TCRs associate with the adapter molecule CD3, which is a complex of five polypeptide chains (γ, δ, ε, ζ, and η). CD3 contains immunoreceptor tyrosine-based activation motifs (ITAMs) that are phosphorylated upon TCR engagement, leading to downstream signaling events that activate T cells. CD28 is a costimulatory receptor on T cells that interacts with the ligands CD80 and CD86 on antigen-presenting cells, but it is not directly involved in TCR signaling. Igα and Igβ are associated with the B cell receptor (BCR), which is structurally similar to the TCR but recognizes soluble antigens instead of peptide-MHC complexes.

TCRs Associate with the Adapter Molecule