Predict the effect of p16 on the cell cycle of dividing cells.

Question

Quizplus · Accepted Answer

p16 is a tumor suppressor protein that inhibits the activity of cyclin-dependent kinases (CDKs), especially CDK4 and CDK6, which are required for progression from G1 to S phase of the cell cycle. When cells are dividing, p16 stops the cell cycle from progressing past the G1 checkpoint, which slows down the division rate of cells. Therefore, the effect of p16 on the cell cycle of dividing cells is decreased cell cycle progression.

Predict the Effect of P16 on the Cell Cycle of Dividing