Cytokine receptors that lack an intrinsic kinase domain transmit signals primarily through:

Question

Quizplus · Accepted Answer

Cytokine receptors that lack an intrinsic kinase domain transmit signals primarily through activation of cytoplasmic kinases. This is achieved through association with Janus kinases (JAKs), which become activated upon cytokine binding and phosphorylate the receptor, creating docking sites for downstream signaling proteins. These signaling proteins, including STATs, are then phosphorylated by JAKs and translocate to the nucleus to activate gene expression.

Cytokine Receptors That Lack an Intrinsic Kinase Domain Transmit Signals