Splenomegaly as a result of bone marrow failure is indicative of:

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Splenomegaly (enlargement of the spleen) is often a consequence of bone marrow failure because the spleen compensates for the loss of bone marrow function by initiating extramedullary hematopoiesis (production of blood cells outside of the bone marrow). As the spleen fills with new blood cells, it can become enlarged. Liver disease, an accelerated immune response, and nuclear asynchrony are not typically associated with splenomegaly due to bone marrow failure.

Splenomegaly as a Result of Bone Marrow Failure Is Indicative