Patients with Sickle-Cell Disease Suffer from Vaso-Occlusive Crises Because

Patients with sickle-cell disease suffer from vaso-occlusive crises because:

A) The altered hemoglobin facilitates the formation of bar-shaped hemoglobin crystals that occlude blood vessels.
B) The altered hemoglobin impairs the ability of hemoglobin to effectively transport oxygen that causes vaso-occlusion.
C) The altered hemoglobin facilitates tactoid crystal formation that alters the shape of the red blood cell, resulting in impeded blood flow in vessels.
D) The altered hemoglobin interferes with globin chain assembly, which impedes blood flow in the vessels.