The cytopenias associated with MDS are due to:

Question

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The cytopenias associated with MDS are primarily due to dyshematopoiesis, which is the abnormal development of blood cells in the bone marrow. This results in the production of insufficient numbers of mature blood cells, leading to anemia, thrombocytopenia, and neutropenia. Bone marrow replacement, hypoplasia of the bone marrow, and decreased cytokine production may contribute to some cases of cytopenia, but dyshematopoiesis is the primary mechanism.

The Cytopenias Associated with MDS Are Due To