A sample has the following test results: hemoglobin 9 g/dL; autohemolysis is increased after 48 hours; increased hemolysis is observed with the Ham test and sucrose hemolysis test.Based on these findings, what is the patient most likely suffering from?

Question

Quizplus · Accepted Answer

The combination of low hemoglobin, increased autohemolysis, and positive results on both the Ham test and sucrose hemolysis test are indicative of paroxysmal nocturnal hemoglobinuria (PNH), a rare disorder characterized by abnormal red blood cell destruction and hemoglobinuria. HS (hereditary spherocytosis) may also present with hemolysis and anemia, but the increased autohemolysis seen in this sample is not typical of HS. HE (hereditary elliptocytosis) may cause hemolytic anemia, but is not associated with increased autohemolysis. PCH (paroxysmal cold hemoglobinuria) may present with hemolysis and hemoglobinuria, but would require specific testing to diagnose.

A Sample Has the Following Test Results: Hemoglobin 9 G/dL;