Paroxysmal nocturnal hemoglobinuria has four basic disease mechanisms: hyperhemolysis, venous thrombosis, infection, and bone marrow hypoplasia. Which of these mechanisms is the most severe complication?

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Venous thrombosis is the most severe complication of paroxysmal nocturnal hemoglobinuria because it can lead to life-threatening complications such as pulmonary embolism and stroke. Hyperhemolysis can cause anemia and hemoglobinuria, but it is not immediately life-threatening. Infection and bone marrow hypoplasia are also serious complications, but they are more commonly seen in cases of aplastic anemia.

Paroxysmal Nocturnal Hemoglobinuria Has Four Basic Disease Mechanisms: Hyperhemolysis, Venous