Mary,a 7-year-old,was admitted to the hospital after experiencing severe anemia following a respiratory infection.Her father has a history of RBC membrane abnormality and recently underwent a splenectomy to help alleviate the problem.Upon examination,it was revealed that Mary had hepatosplenomegaly and slight bruising on her forearms.A CBC was ordered,with the following results: HGB 9.0 g/dL
HCT 24%
WBC 11 × 10⁹/L
RBC 3.8 × 10¹²/L
MCV 102 fl
MCH 25 pg
MCHC 40%
PLT 275 × 10⁹/L
Peripheral smear: moderate macrocytes and stomatocytes
Which of the following is most consistent with a presumptive diagnosis in this case?

Question

Quizplus · Accepted Answer

The patient's symptoms (hepatosplenomegaly, anemia, slight bruising) and lab results (moderate macrocytes and stomatocytes) are consistent with hereditary spherocytosis (HS), a genetic disorder affecting the red blood cell membrane. The history of the patient's father having RBC membrane abnormality also supports this diagnosis. The other options (PNH, DHS, HE) do not fit the clinical picture described.

Mary,a 7-Year-Old,was Admitted to the Hospital After Experiencing Severe Anemia