In PNH, cells are susceptible to complement induced lysis.This is thought to be due to the lack of what two regulating factors?

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Quizplus · Accepted Answer

PNH cells are susceptible to complement induced lysis due to the lack of two regulating factors, Decay Accelerating Factor (DAF) and Membrane Inhibitor of Reactive Lysis (MIRL). LCAT and lipoprotein are not related to complement regulation, and HDL and VLDL are types of lipoproteins that do not regulate complement. Beta and alpha lipoproteins are not involved in complement regulation either.

In PNH, Cells Are Susceptible to Complement Induced Lysis