A 53-year-old Italian male was hospitalized with increased fatigue and hemoglobinuria. Patient history revealed his last ingested meal contained fava beans. G6PD levels were performed 3 months later, and the result was 5%. Based on these findings, which class of G6PD variant is most likely affected?

Question

Quizplus · Accepted Answer

The patient is presenting with symptoms of favism, which occurs due to G6PD deficiency. The fact that his G6PD levels are still low 3 months later suggests a class II variant. Class I variants are severe and usually result in neonatal jaundice or chronic hemolytic anemia, often requiring blood transfusions. Class III variants have moderate enzyme deficiency and generally do not result in hemolysis unless triggered by oxidative stress. Class IV variants have mild enzyme deficiency, and hemolysis is rare.

A 53-Year-Old Italian Male Was Hospitalized with Increased Fatigue and Hemoglobinuria