A child presents to the Emergency Department with clinical findings of bloody diarrhea and fever.Laboratory findings reveal an elevated neutrophil count, increased C-reactive protein, thrombocytopenia, and a decreased haptoglobin.These findings are associated with what diagnosis? ?

Question

Quizplus · Accepted Answer

The clinical findings and laboratory results are indicative of Hemolytic Uremic Syndrome (HUS). HUS is a type of thrombotic microangiopathy that primarily affects the kidneys and can lead to acute kidney injury. The bloody diarrhea is caused by the microangiopathic hemolytic anemia, and the fever is likely due to the underlying infection causing the HUS. The elevated neutrophil count and increased C-reactive protein suggest an inflammatory response, while thrombocytopenia and decreased haptoglobin suggest a hemolytic process. TTP (A) presents with similar symptoms to HUS, but the laboratory findings would also include a low platelet count, prolonged bleeding time, and an elevated LDH. DIC (C) is another type of thrombotic microangiopathy, but it is associated with underlying conditions such as sepsis, cancer, and trauma. HELLP syndrome (D) is a complication of pregnancy that can present similarly to HUS, but it is characterized by microangiopathic hemolytic anemia, elevated liver enzymes, and low platelet count.

A Child Presents to the Emergency Department with Clinical Findings