Which of the following disorders is characterized by a defect in sphingomyelinase, which results in macrophages with a foamy appearance?

Question

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Niemann-Pick disease is characterized by a defect in sphingomyelinase, resulting in accumulation of sphingomyelin within cells, particularly macrophages, which gives them a foamy appearance. Gaucher's disease is characterized by a defect in glucocerebrosidase and accumulation of glucocerebroside within cells. Fabry's disease is characterized by a defect in alpha-galactosidase A and accumulation of globotriaosylceramide within cells. Tay-Sachs disease is characterized by a defect in hexosaminidase A and accumulation of GM2 ganglioside within cells.

Which of the Following Disorders Is Characterized by a Defect