Which test or tests support the theory that the abnormal cells in MDS are clones derived from an abnormal pluripotent stem cell?

Question

Quizplus · Accepted Answer

Cytogenetic, G6PD isoenzyme, and molecular studies can identify chromosomal abnormalities and trace the lineage of abnormal cells, which support the theory that MDS arises from a single abnormal pluripotent stem cell. Cytochemical studies and peripheral blood smear examination could provide information about the morphology and differentiation of the abnormal cells, but they cannot confirm the clonal origin of the cells. Bone marrow examination is useful to diagnose MDS and evaluate disease severity, but does not provide information on the clonal origin of the cells.

Which Test or Tests Support the Theory That the Abnormal