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A 45-year-old female sees her physician because of unexplained bruising on her upper torso. The physician takes a history, and nothing remarkable is noted. Physical examination reveals a palpable liver and spleen. CBC results reveal a platelet count of 5,000/µL and WBC count of 12,000/µL with 80% blasts and 15% promyelocytes present. Additional CBC findings include: Hgb: 8.7 g/dL and Hct: 25% normal indices.
Bone marrow findings: hypercellular marrow with 47% myeloblasts present. Nucleated erythroblasts: 22%; promyelocytes: 28%; megakaryopoiesis appears normal.
Cytogenetic analysis: t (15, 17) present.
-Which of the following laboratory findings would be most consistent with this clinical picture?

Question

Quizplus · Accepted Answer

Auer rods are cytoplasmic inclusions that are characteristic of acute myeloid leukemia (AML). They are composed of a protein called myeloperoxidase, which is a marker of myeloid differentiation. In this case, the patient has AML with a t(15,17) translocation, which is associated with the presence of Auer rods.

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