The patient presents with acute leukemia.The blast morphology is of neutrophil lineage with Auer rods and pseudo-Pelger-Huët nuclei; the immunophenotype is positive for CD33, CD13, CD34, and CD56 with a positive TdT, myeloperoxidase, and Sudan Black B.Cytogenetic analysis reveals a t(8;21)(q22;q22) translocation in the majority of the blasts.Which classification of AML best fits this morphology, immunophenotyping, and cytotechemistry?

Question

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The blast morphology, immunophenotyping, and cytogenetic analysis suggest a diagnosis of AML with recurrent genetic abnormalities, specifically t(8;21)(q22;q22). This translocation is characteristic of AML with maturation (AML-M2) and is associated with a better prognosis than other AML subtypes.

The Patient Presents with Acute Leukemia