A male of 65 years of age is seen at a local hospital with symptoms of enlarged lymph nodes and possible gastrointestinal tract problems.The peripheral blood smear revealed cells resembling diffuse large B cell lymphoma.The FISH studies demonstrated the translocation of BCL-1.What is the probable disease with these results?

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Quizplus · Accepted Answer

The symptoms along with the presence of diffuse large B cell lymphoma and translocation of BCL-1 are indicative of mantle cell lymphoma (MCL). MALT (mucosa-associated lymphoid tissue) lymphoma does not typically present with enlarged lymph nodes and the FISH studies would show a different translocation. Burkitt's leukemia typically presents in children or young adults and is characterized by a different translocation (8;14 or 2;8). Follicular lymphoma presents with follicular patterns on histology and a different translocation (14;18).

A Male of 65 Years of Age Is Seen at a Local