A physician has confirmed von Willebrand's disease in his patient.Further testing is needed to determine which subtype the patient has.Multimer analysis is performed, and comes back normal.What is the most probable explanation for this?

Question

Quizplus · Accepted Answer

Type I VWD is characterized by a quantitative decrease in von Willebrand factor (VWF), but the multimers are usually normal. Therefore, a normal multimer test in the presence of VWF deficiency is consistent with type I VWD. Option A is incorrect because the patient has already been confirmed to have VWD. Option C is incorrect because Bernard-Soulier syndrome (BSS) is characterized by a deficiency or dysfunction of glycoprotein Ib. Option D is unlikely and not a probable explanation.

A Physician Has Confirmed Von Willebrand's Disease in His Patient