What is the screening test of choice in the work-up of PNH?

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The sugar-water test, also known as the Ham test, is the screening test of choice in the work-up of PNH. It detects the presence of complement-sensitive red blood cells and measures the susceptibility of the patient's red blood cells to complement-mediated lysis in an acidified sugar solution. Acid elution of hemoglobin F is a test for sickle cell anemia, hemoglobin A2 estimation is a test for thalassemia, and soluble transferrin receptor is a test for iron deficiency anemia.

What Is the Screening Test of Choice in the Work-Up