The principle that relies on detecting resistance as cells pass through a photo-detector and is that used by most of the major hematology analyzers is:

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Impedance relies on detecting changes or interruptions in an electrical current as cells pass through a small aperture, and this technology is widely used in hematology analyzers. Spectrophotometry involves measuring the absorbance and transmission of light through a sample, while radio frequency and MAPSS technology are used in other medical applications but not typically in hematology.

The Principle That Relies on Detecting Resistance as Cells Pass