A patient is admitted with prolonged epistaxis and prolonged bleeding from a recent tooth extraction.Initial screening workup reports prolonged APTT and BT, and abnormal aggregation on the PFA.Which of the following tests would help define the disorder?

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Quizplus · Accepted Answer

All three tests (von Willebrand's factor activity, von Willebrand's factor antigen, and Factor VIII assay) are important for diagnosing a bleeding disorder. Prolonged APTT suggests a possible problem with the intrinsic pathway, which is often associated with deficiencies in coagulation factors VIII, IX, XI, and XII, as well as von Willebrand factor. The abnormal aggregation on PFA suggests a possible defect in platelet function, which can be a result of a deficiency in von Willebrand factor. Therefore, all three tests should be performed to assess for a possible von Willebrand disease or other coagulation disorder.

A Patient Is Admitted with Prolonged Epistaxis and Prolonged Bleeding