Originally called Byzantium,and now known as Istanbul,________ became the world's largest settlement after the decline of Rome,and remained the largest settlement for most of the next 1,000 years.

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The city, which was initially called Byzantium, was later renamed Constantinople when it became the capital of the Byzantine Empire under Constantine the Great in 324 AD. It became the world's largest settlement and a prominent cultural, economic, and political center for most of the next 1,000 years.

Originally Called Byzantium,and Now Known as Istanbul,________ Became the World's