The Huntington disease (HD) allele was discovered
A) by mapping it to blood enzyme genes,based on Lod scores of -2.
B) through pedigree analysis alone.
C) by linkage to a DNA genetic marker,D4S10 with a Lod score of 8.53.
D) through mapping to known homologs in other organisms such as mice.
E) through direct sequencing of mutations identified by SNPs.
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