During DNA replication in E. coli, what is the role of DnaA?
A)DnaA is a region of DNA recognized by the replisome where replication is initiated.
B)DnaA bends DNA, hydrolyzing the hydrogen bonds in the 13-mer region of oriC and creating an open complex.
C)DnaA is a helicase that uses ATP to hydrolyze hydrogen bonds and separate DNA strands.
D)DnaA carries the helicase protein to the open region of DNA where hydrolysis and strand separation will occur.
E)DnaA prevents reannealing of the separated strands so replication can proceed.

Question

Quizplus · Accepted Answer

DnaA binds to specific sequences in the oriC region and forms a complex that bends the DNA and creates an open complex by hydrolyzing the hydrogen bonds in the 13-mer region of oriC. This allows other proteins, such as helicases and polymerases, to access the separated strands for replication.

During DNA Replication in E